With the formation of Pakistan Girl Guides Association in 1947, a separate provincial Guide Branch was organized in the province of Sindh with the Provincial Commissioner as head of the branch. The branch functioned as an independent unit up to 1954. In 1955 the west wing of Pakistan was integrated into a single unit. As a result, the Girl Guides Association of West Pakistan came into being. Provincial branch of Sindh was given the status of a divisional branch under the supervision of divisional Guide Commissioner. In 1972 after the dissolution of one unit the Sindh Branch was revived with the divisional structure according to the new administrative division of the government as listed below:

• Karachi Region
• Hyderabad Region